In 2015, the Health Council of UNASUR approved the Strategic Guidelines of ISAGS – a framework document that proposes 5 lines of action for the institute:

Generation, production and dissemination of critical, innovative and transformative knowledge of health policies and systems for the reduction of social inequalities
Elaboration of studies and research along with UNASUR Technical Groups and Structuring Networks, publication of books, creation of databases.
Support for the training of strategic personnel for the formulation of policies and management of health systems.
Conducting workshops, seminars, on-site and virtual courses, international internship program.
Inter-sectorial articulation to generate communication spaces between other sectors and health in the member countries of UNASUR.
Mapping of the agenda of the Sectoral Councils of UNASUR.
Contribution to the democratization of access knowledge and information of health.
Creation of several communication channels, such as the website, the pages on social networks, the magazine Health to the South, the weekly newsletter as well as hosting debates at the Institute's headquarters.
Strengthening of the Health Diplomacy in UNASUR, promoting the construction of a South American vision and reinforcing critical reflection on global health, aligning positions and promoting a virtuous circle for health cooperation.
Support to countries and participation in regional and global Health forums, subscription and monitoring of agreements with similar institutions and other regional integration organizations.